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NetRNA: Networks of Regulatory RNAs across kingdoms and dynamical responses to biotic and abiotic stresses
Latest News
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8 oct 2018 à 11h00 Seminar given by Prof. Brenda BASS (2018-09-12)
Distinguished Professor &
H.A. and Edna Benning Presidential Endowed Chair
Dept. of Biochemistry, University of Utah, USA "Understanding the roles and regulation of Dicer in antiviral defense"
>>Read more8 juin 2018 : Seminar given by Prof. Sven DIEDERICHS (2018-05-23)
German Cancer Research Center, Division of RNA Biology Heidelberg & Cancer & University Hospital, Division of Cancer Research Freiburg
Title : The dark matter of the cancer genome : long non-coding RNAs
and RNA-dependent proteins in cancer
6 avril 2018 Seminar Prof. Wolfgang HESS (2018-04-06)
Genetics and Experimental Bioinformatics
University of Freiburg
Title : RNase E endonuclease as a CRISPR-Cas maturation enzyme and in the sRNA-mediated control of gene
29 mars 2018 : Seminar Prof. Blake MEYERS (2018-03-29)
Donald Danforth Plant Science Center
University of Missouri - Columbia - USA
Title : The diversity, function, and evolution of secondary siRNA pathways in plants
23 mars 2018 Seminar Prof. Dr. Rolf BACKOFEN (2018-03-23)
Institut für Informatik
Albert-Ludwigs-Universität Freiburg
Title : Computational Genomics: Informatics Problems and Applications in Life Sciences
17 November : 5Fifth Meeting of the LabEx NetRNA PhD-students (2017-10-22)
Invited speaker : Dr Lars Dölken Würburg
Previous News **************************************************************************************************************************Presentation
The NetRNA consortium, coordinated by Dr. Pascale Romby, gathers eleven CNRS teams working on different aspects of genes expression regulation by RNA in various organisms (Institut de Biologie Moléculaire et Cellulaire and Institut de Biologie Moléculaire des Plantes). These teams are respectively leaded by: Magali Frugier, Sébastien Pfeffer, Pascale Romby and Michael Ryckelynck (UPR 9002), Jean-Luc Imler, Nicolas Matt and Carine Meignin (UPR 9022), Todd Blevins, Dominique Gagliardi, Damien Garcia and Pascal Genschik (UPR 2357).
The general objective of the NetRNA network is to advance knowledge on functions of the regulatory RNAs, mainly small ncRNAs, their targets and mechanisms. Our main objective is to integrate these regulatory RNAs into the general network of gene expression in a variety of pathogens (bacteria, viruses, parasites) and of organisms such as plants, insects, and mammals. A special focus will be directed towards regulatory RNAs that play a role in development, stress-related responses, immune responses, host-pathogen interactions, and in human diseases.
Main objectives
- Regulatory RNAs targeting mRNAs and their regulatory networks in various organisms (plants, mammals, insects) and pathogens (bacteria, viruses, parasites)
- Dynamics of regulatory networks in response to environmental changes, stress conditions, host-pathogen interactions
Task 1: Molecular machineries of regulatory RNAs (HTS, MS)
- Understanding of regulatory RNAs, their targets, and the multi-protein effector complexes involved in their functionality and regulation
- Elucidate the regulatory mechanisms at the molecular level and rules that dictate specific recognition between RNAs and their targets
Task 2: Regulatory RNAs, biotic and abiotic stresses (HTS, imaging)
- Profiling regulatory RNAs under stress conditions
- Impact of biotic and abiotic stresses on molecular machineries
- Localization of regulatory RNAs and their molecular machineries
Task 3: Regulatory RNAs: towards system biology (HTS, microfluidics, bioinformatics)
- Establishment of networks
- Dynamics of the networks: single cell studies