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NetRNA: Networks of Regulatory RNAs across kingdoms and dynamical responses to biotic and abiotic stresses

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The NetRNA consortium, coordinated by Dr Eric Westhof, gathers eleven CNRS teams working on different aspects of genes expression regulation by RNA in various organisms (Institut de Biologie Moléculaire et Cellulaire and Institut de Biologie Moléculaire des Plantes). These teams are respectively leaded by: Magali Frugier, Yaser Hashem, Fabrice Jossinet, Sébastien Pfeffer, Pascale Romby and Eric Westhof (UPR 9002), Jean-Luc Imler and Jean-Marc Reichhart (UPR 9022), Patrice Dunoyer, Dominique Gagliardi and Pascal Genschik (UPR 2357).

The general objective of the NetRNA network is to advance knowledge on functions of the regulatory RNAs, mainly small ncRNAs, their targets and mechanisms. Our main objective is to integrate these regulatory RNAs into the general network of gene expression in a variety of pathogens (bacteria, viruses, parasites) and of organisms such as plants, insects, and mammals. A special focus will be directed towards regulatory RNAs that play a role in development, stress-related responses, immune responses, host-pathogen interactions, and in human diseases.

Main objectives

Task 1: Molecular machineries of regulatory RNAs (HTS, MS)

Task 2: Regulatory RNAs, biotic and abiotic stresses (HTS, imaging)

Task 3: Regulatory RNAs: towards system biology (HTS, microfluidics, bioinformatics)