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NetRNA: Networks of Regulatory RNAs across kingdoms and dynamical responses to biotic and abiotic stresses
Latest News
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April 28, 2017 Seminar given by Prof. Lars Doelken (2017-04-21)
(Institut für Virologie & Immunologie Julius-Maximilians-Universität Würzburg, Allemagne)
Title : Systems biology analysis of lytic HSV-1 infectiona
January 6, 2017 : Seminar given Pascale Cossart (2016-11-25)
Institut Pasteur, Paris
RNA mediated regulation in bacteria: lessons from Listeria
>>Read more20 juin : Seminar given by Dr Chirlmin JOO (2016-05-23)
Kavli Institute of NanoScience
Delft University of Technology
The Netherlands"Why Argonaute is needed to make microRNA target search fast and reliable"
>>Read more25 mai 2016 : Seminar given by Prof. Gerhart Wagner, Uppsala University (2016-04-25)
Some thoughts on why bacteria
use regulatory RNAs
>>Read more26 mai 11h00 : Seminar Julius Brennecke, IMBA, Vienna, Austria (2016-03-22)
The piRNA pathway - a small RNA based genome defense system
>>Read more19 mai 2016 : Seminar Prof Mark LINDSAY (2016-03-01)
Dept of Pharmacy and Pharmacology, University of Bath, United Kingdom
"Are lont non-coding RNA novel regulators of the inflammatory response ?
Previous News **************************************************************************************************************************Presentation
The NetRNA consortium, coordinated by Dr Eric Westhof, gathers eleven CNRS teams working on different aspects of genes expression regulation by RNA in various organisms (Institut de Biologie Moléculaire et Cellulaire and Institut de Biologie Moléculaire des Plantes). These teams are respectively leaded by: Magali Frugier, Yaser Hashem, Fabrice Jossinet, Sébastien Pfeffer, Pascale Romby and Eric Westhof (UPR 9002), Jean-Luc Imler and Jean-Marc Reichhart (UPR 9022), Patrice Dunoyer, Dominique Gagliardi and Pascal Genschik (UPR 2357).
The general objective of the NetRNA network is to advance knowledge on functions of the regulatory RNAs, mainly small ncRNAs, their targets and mechanisms. Our main objective is to integrate these regulatory RNAs into the general network of gene expression in a variety of pathogens (bacteria, viruses, parasites) and of organisms such as plants, insects, and mammals. A special focus will be directed towards regulatory RNAs that play a role in development, stress-related responses, immune responses, host-pathogen interactions, and in human diseases.
Main objectives
- Regulatory RNAs targeting mRNAs and their regulatory networks in various organisms (plants, mammals, insects) and pathogens (bacteria, viruses, parasites)
- Dynamics of regulatory networks in response to environmental changes, stress conditions, host-pathogen interactions
Task 1: Molecular machineries of regulatory RNAs (HTS, MS)
- Understanding of regulatory RNAs, their targets, and the multi-protein effector complexes involved in their functionality and regulation
- Elucidate the regulatory mechanisms at the molecular level and rules that dictate specific recognition between RNAs and their targets
Task 2: Regulatory RNAs, biotic and abiotic stresses (HTS, imaging)
- Profiling regulatory RNAs under stress conditions
- Impact of biotic and abiotic stresses on molecular machineries
- Localization of regulatory RNAs and their molecular machineries
Task 3: Regulatory RNAs: towards system biology (HTS, microfluidics, bioinformatics)
- Establishment of networks
- Dynamics of the networks: single cell studies