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NetRNA: Networks of Regulatory RNAs across kingdoms and dynamical responses to biotic and abiotic stresses
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26 mai 11h00 : Seminar Julius Brennecke, IMBA, Vienna, Austria (2016-03-22)
The piRNA pathway - a small RNA based genome defense system
>>Read more19 mai 2016 : Seminar Prof Mark LINDSAY (2016-03-01)
Dept of Pharmacy and Pharmacology, University of Bath, United Kingdom
"Are lont non-coding RNA novel regulators of the inflammatory response ?
29 avril 2016 : Seminar givenby Hiroaki Suga (2016-02-19)
The University of Tokyo
A RaPID way to discover potent macrocyclic peptides for therapeutic uses
7 avril 2016 14h30 : Seminar Prof Hervé LE HIR (2016-02-12)
Ecole Normale Supérieure de Paris
The versatility of RNA helicases highlighted by the
Exon Junction Complex
7 avril 2016 : 4th Meeting of the NetRNA PhD Students (2016-02-12)
Conférencier invité : Professeur Hervé Le Hir Ecole Normale Supérieure de Paris
15 mars 2016 : Seminar given by Prof. Guillaume Chanfreau (2016-02-11)
UCLA - Los Angeles - USA
Mapping of RNA 3’-ends reveals new mechanisms
of degradation and transcription termination
>>Read more29 janvier 2016 : Seminar given by Prof. Brian Cullen (2016-02-10)
Duke University Medical Center - Department of Molecular Genetics and Microbiology - Durham, NC USA
Viruses, microRNAs and RNA interference
30 octobre 2015 : Séminar given by Tod Blevins (2016-02-01)
Tod Blevins : Junior Chair IBMP
22 octobre à 10h30 : Seminar Prof Narry Kim (2015-09-30)
Prof. Narry Kim, School of Biological Sciences, Seoul, Corée
>>Read more18 June à 9h30 : Seminar Prof. Shoshy ALTUVIA (2015-06-10)
The Hebrew University, Jerusalem, Israel
>>Read more17 June 2015 : Seminar given by John RINN (2015-05-27)
Harvard University, Cambridge, USA
"Regulatory roles of RNA repeats"
>>Read more24 April 2015 : Seminar given by Ciaran Condon (2015-04-24)
Control of messenger RNA decay in Gram-positives
Institut de Biologie Physicochimique - PARIS
>>Read more23 avril : Seminar given Prof. Dr. Mak HELM, Johannes Gutenberg Universität Mainz (2015-04-23)
New methods for the detection of RNA modifications
>>Read more17 avril 2015 : 3rd Labex PhD/Postdocs Meeting (2015-04-17)
Annual meeting of the Labex teams with an invited speaker (B. Seraphin, IGBMC) and six communications by Labex new phD students.
17 avril 2015 : Seminar Bertrand Séraphin, IGBMC - Strasbourg (2015-04-17)
Starting from the end: from eukaryotic mRNA decay mechanisms to diseases
Conférence plénière dans le cadre de la journée scientifique des doctorants du LabEx Net RNA
26 mars : Seminar given by Prof. H. Vaucheret (2015-03-26)
26 mars : Seminar given by Prof. H. Vaucheret
Old and new RNAi components
17 mars 2015 : 2015 Winter School Course for PhD Students (2015-03-17)
Machineries in post-transcriptional regulation Advances, challenges and opportunities organized by the LabEx NetRNA. Speakers : D. Gagliardi, Y. Hashem.
20-22 novembre 2014 : Joint Meeting LabEx NetRNA and LabEx Mitocross and SAB Meeting (2014-11-20)
20-22 November 2014 - Le Bischenberg + SAB Meetings
7 novembre 2014 : Seminar given by Prof.Nenad Ban, ETH Zürich (2014-11-07)
Beyond the prokaryotic ribosomes
>>Read more10 octobre 2014 : Seminar given by Prof. Scott Poethig, University of Pennsylvania Department of Biology (2014-10-10)
miRNAs and the regulation of developmental timing in plants
>>Read more11 juin 2014 : Seminar given by Prof. Andreas Pichlmair (2014-05-19)
Prof. Andreas Pichlmair, from the Innate Immunity laboratory; Max-Planck Institute for Biochemistry - Martinsried / Munich Germany, will give a seminar entitled "Viral nucleic acid in the headlock of the innate immune system" in the seminar room of the IBMC, the 11th of June 2014, at 11 am.
15 avril 2014 : 2nd Labex PhD/Postdocs Meeting (2014-04-15)
Annual meeting of the Labex teams with an invited speaker (W. Filipowicz) and three communications by Labex members. A poster session describing results of all Labex Teams made by the PhD students and Postdocs is organized after the speachs.
Une Chaire Gutenberg 2014 attribuée à Witold FILIPOWICZ (2014-04-01)
Witold FILIPOWICZ, Senior Staff Scientist et Group Leader à l’Institut Friedrich Mischer pour la recherche biomédicale de Bâle et professeur à l’Université de Bâle, sera accueilli à l’IBMC par l’unité « Architecture et réactivité de l’ARN » grâce à l’octroi d’une chaire Gutenberg. Il participera tout particulièrement aux travaux des équipes du LabEx NetRNA de l’IBMC et de l’IBMP.
>>Read more24 mars 2014 : Scientific Committee Members Meeting (2014-03-24)
Le comité est composé des directeurs et directeurs-adjoints des 3 unités, des représentants des tutuelles (CNRS) et de l'IDEX (Université de Strasbourg)
17 février 2014 : Winter School Course for PhD Student (2014-02-17)
Training course Ecole Doctorale Vie et Santé : MicroRNAs and regulator RNAs organized by the labEx NetRNA. Speakers : E.Westhof, J.L. Imler, P.Romby, P.Dunoyer, S. Pfeffer, W. Filipowicz
24-25 septembre 2013 : 2nd SAB meeting (2013-09-24)
The second SAB meeting will be organized on September 24 & 25, 2013, in Itterswiller. During 2 days the consortium will present their internal results to the Scientific Advisory Board. The SAB committee is composed of Thomas Baumer, Witold Filipowicz, Fabrice Kolb (Novartis), Gunter Meister, Benjamin Moingeon (GATC), Bertrand Séraphin, Olivier Voinnet and Joerg Vogel.
When RNA degradation pathways meet proteolytic machineries (2012-07-19)
In the frame of the Labex NetRNA, a team at IBMP-CNRS revealed a novel mechanism that controls the homeostasis of the key regulatory protein of RNA silencing: ARGONAUTE1.
>>Read more5-6 juillet 2012 : Kick-off Meeting - SAB (2012-07-05)
5-6 Juillet 2012
Latest News **************************************************************************************************************************Presentation
The NetRNA consortium, coordinated by Dr Eric Westhof, gathers eleven CNRS teams working on different aspects of genes expression regulation by RNA in various organisms (Institut de Biologie Moléculaire et Cellulaire and Institut de Biologie Moléculaire des Plantes). These teams are respectively leaded by: Magali Frugier, Yaser Hashem, Fabrice Jossinet, Sébastien Pfeffer, Pascale Romby and Eric Westhof (UPR 9002), Jean-Luc Imler and Jean-Marc Reichhart (UPR 9022), Patrice Dunoyer, Dominique Gagliardi and Pascal Genschik (UPR 2357).
The general objective of the NetRNA network is to advance knowledge on functions of the regulatory RNAs, mainly small ncRNAs, their targets and mechanisms. Our main objective is to integrate these regulatory RNAs into the general network of gene expression in a variety of pathogens (bacteria, viruses, parasites) and of organisms such as plants, insects, and mammals. A special focus will be directed towards regulatory RNAs that play a role in development, stress-related responses, immune responses, host-pathogen interactions, and in human diseases.
Main objectives
- Regulatory RNAs targeting mRNAs and their regulatory networks in various organisms (plants, mammals, insects) and pathogens (bacteria, viruses, parasites)
- Dynamics of regulatory networks in response to environmental changes, stress conditions, host-pathogen interactions
Task 1: Molecular machineries of regulatory RNAs (HTS, MS)
- Understanding of regulatory RNAs, their targets, and the multi-protein effector complexes involved in their functionality and regulation
- Elucidate the regulatory mechanisms at the molecular level and rules that dictate specific recognition between RNAs and their targets
Task 2: Regulatory RNAs, biotic and abiotic stresses (HTS, imaging)
- Profiling regulatory RNAs under stress conditions
- Impact of biotic and abiotic stresses on molecular machineries
- Localization of regulatory RNAs and their molecular machineries
Task 3: Regulatory RNAs: towards system biology (HTS, microfluidics, bioinformatics)
- Establishment of networks
- Dynamics of the networks: single cell studies